Results of PRISM-EZ trial Published

Some of you may be familiar with the Paget’s Randomized trial of Intensive versus Symptomatic Management (PRISM) study. The extension of the trial was called the PRISM-EZ study, standing for PRISM, Extension with Zoledronic acid.

The results of the PRISM-EZ study suggest that in patients with established Paget’s disease, intensive bisphosphonate therapy to suppress bone turnover, does not provide any benefit. The study shows that in patients with well-established disease, the focus should be on using bisphosphonate treatment to control bone pain that is thought to be due to disease activity. One of the researchers and co-author of the paper, Professor Stuart Ralston, from the University of Edinburgh, who led the study commented, “The take home message from PRISM-EZ is that doctors should be treating the patient with Paget’s disease and not simply treating the level of Alkaline Phosphatase (ALP)!” He also added that the results of PRISM-EZ applied to people who had established Paget’s disease, and that it wasn’t known if bisphosphonate treatment in early asymptomatic disease is beneficial. You may be aware of, and even be part of research known as the ZiPP study (Zoledronic acid in the Prevention of Paget's), which is addressing this issue. We look forward to the results in due course.

A more detailed summary of this research and a comment from our Vice-Chairman can be found by following this link to our Research Updates. It is also available in the May 2017 edition of our newsletter. All our newsletters can be found in the members' area of this website. Registration to receive our newsletter is free - for details follow this link.

Tan, A., Goodman, K., Walker, A., Hudson, J., MacLennan, G. S., Selby, P. L., Fraser, W. D., Ralston, S. H. and for the PRISM-EZ Trial Group (2017), Long-Term Randomized Trial of Intensive Versus Symptomatic Management in Paget's Disease of Bone: The PRISM-EZ Study. Journal of Bone Mineral Research.