Paget's Guideline Published
A new clinical Guideline, for the diagnosis and management of Paget’s Disease of Bone in adults, was commissioned by the Paget's Association, with the support of the European Calcified Tissue Society and the International Osteoporosis Society. The Guideline was published in 2019 and provides evidence-based recommendations for the diagnosis and management of Paget’s disease. It allows health professionals to consider the available evidence and discuss options with the patient. The full Guideline has now been published in the Journal of Bone and Mineral Research. You can download a PDF copy below.
The following *recommendations were highlighted by the Guideline Development Group as the most important:
1. Radionuclide bone scans, in addition to targeted radiographs, are recommended as a means of fully and accurately defining the extent of the metabolically active disease in patients with Paget’s Disease of Bone.
2. Serum total alkaline phosphatase (ALP) is recommended as a first line biochemical screening test, in combination with liver function tests, in screening for the presence of metabolically active Paget’s Disease of Bone.
3. Bisphosphonates are recommended for the treatment of bone pain associated with Paget’s disease. Zoledronic acid is recommended as the bisphosphonate most likely to give a favourable pain response.
4. Treatment aimed at improving symptoms is recommended over a treat‑to-target strategy aimed at normalising total ALP in Paget’s Disease of Bone.
5. Total hip or knee replacements are recommended for patients with Paget’s Disease of Bone who develop osteoarthritis, for whom medical treatment is inadequate. There is insufficient information to recommend one type of surgical approach over another.
You can download a PDF of the full Guideline here: *Diagnosis and Management of Paget’s Disease of Bone in Adults - A Clinical Guideline 2019
New Facts Booklet. The Paget's Association has updated its booklet, 'Paget's - The Facts', in line with the new Guideline. This will be available in the coming weeks to download from the member's area of this website and also by contacting the Paget's Association on 0161 7994646 or email [email protected]
In the video below, Professor Mike Stone discusses the Guideline.
Membership of the Paget's Association brings with it many benefits - follow this link for more information about membership.
*Reproduced from Ralston, S. H., Corral‐Gudino, L., Cooper, C., Francis, R. M., Fraser, W. D., Gennari, L., Guañabens, N., Javaid, M. K., Layfield, R., O'Neill, T. W., Russell, R. G., Stone, M. D., Simpson, K. , Wilkinson, D., Wills, R., Zillikens, M. C. and Tuck, S. P. (2019), Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline. J Bone Miner Res. doi:10.1002/jbmr.3657