1. A simple blood test which can be carried out by your GP may show an increased alkaline phosphatase (ALP) level. This could indicate Paget’s disease. A rise in ALP can indicate other conditions so this test is not used in isolation.

    - The ALP can be normal even if Paget's Disease is active - this can happen when Paget's is active in a small area of bone.

    - Active Paget's disease can sometimes be seen as a gradual rise of the ALP within normal limits.

  2. Paget's disease can be seen on a plain x-ray of the affected bone.

  3. An Isotope Bone Scan is used to determine the extent and activity of the disease. Download information sheet (PDF): Isotope Bone Scans

  4. There may be a family history of Paget's Disease.

  5.  A full assessment by a hospital consultant is recommended to determine if treatment is required.

Log-in to read Professor Fraser's article on Blood tests in Paget’s Disease of Bone, which you will find under Information in the Member's Area.