There are still some uncertainties about the causes of Paget’s disease but there is a general understanding that it is due to a combination of inherited and environmental influences.
It is unclear why only certain bones are affected. This may be related to mechanical stresses that are placed on the skeleton at specific sites or differences in the blood supply to these bones. For more information see our Fact's Booklet and Newsletters which are all available in the Member's Area of this website: log-in or register.