Friday 8 July 2005

08:55

Welcome and introduction
Graham Russell (Oxford, UK)

09:00-10:30

Epidemiology and genetics

Chairs: Henry Bone (Detroit, USA)/Peter Selby (Manchester, UK)

09:00

IS1

UPDATE ON THE EPIDEMIOLOGY OF PAGET’S DISEASE
Cyrus Cooper (Southampton, UK)

09:30

IS2

ASPECTS OF PATHOGENESIS OF PAGET’S DISEASE
Tim Cundy (Auckland, New Zealand)

10:00

IS3

EPIDEMIOLOGY AND GENETICS OF PAGET’S DISEASE IN ITALY
Luigi Gennari (Siena, Ialy)

10:20

P1

GENDER INFLUENCE IN SECULAR CHANGES IN PAGET DISEASE
A Conesa, D Rotés Sala, J M Manresa, M P Lisbona, L Pérez Edo, J Carbonell (Barcelona, Spain)

10:30

Coffee

11:00-12:55

Genetics

Chairs: Jacques Brown (Quebec, Canada)/Matthew Brown (Oxford, UK)

11:00

IS4

GENETICS AND ENVIRONMENTAL ORIGINS OF PAGET’S DISEASE
Stuart Ralston (Edinburgh, UK)

11:30

IS5

SEQUESTOSOME MUTATIONS IN PAGET’S DISEASE
Jean Morissette (Quebec, Canada)

11:55

P2

MUTATIONAL ANALYSIS OF P62/SEQUESTOSOME1 GENE P62/SQSTM1) IN A MULTICENTRIC ITALIAN SERIES OF PATIENTS AFFECTED BY PAGET'S DISEASE OF BONE (PDB)
A Falchetti, F Marini F, F Del Monte, D Strigoli, A Gozzini, A Tanini, L Masi, A Amedei, M Di Stefano, G Isaia, G B Rini, M L De Feo, S Maddali, M Matucci Cerinic, M Benucci, A Matucci, G Marin, V Ferioli, M Ulivieri, S Giannini, L Sartori, V Braga, S Adami, L Di Matteo, O Di Munno, S Ortolani, M L Brandi (Florence, Turin, Palermo, Milan, Padua, Verona, Pescara and Pisa, Italy)

12:05

P3

FUNCTIONAL EFFECTS OF PAGET'S DISEASE SQSTM1 MUTATIONS
R Layfield, M S Searle, B Ciani, T Gallagher, P W Sheppard, L J Hocking, S H Ralston, J R Cavey (Nottingham and Aberdeen, UK)

Short orals - Genetics

12:15

P4

SEGREGATION OF TWO DIFFERENT MUTATIONS IN A SPANISH FAMILY WITH PAGET'S DISEASE
G Beyens, A Trujillo, W Van Hul (Antwerp, Belgium and Madrid, Spain)

12:23

P5

A NOVEL MUTATION (K378X) IN THE SEQUESTOSOME 1 GENE ASSOCIATED WITH A SEVERE PHENOTYPE IN PAGET'S DISEASE OF BONE
S L Morgan, L Ward, B K Ward, J Walsh, J Xu, B Stuckey, N Kent, T Ratajczak (Nedlands, Australia)

12:31

P6

-511C>T POLYMORPHISM ON IL1B GENE IS RELATED TO RESPONSE TO BISPHOSPHONATE TREATMENT IN PAGET DISEASE OF BONE
L Corral Gudino, J del Pino, R Gonzalez Sarmiento, C A Montilla, I Pastor, J García Aparicio (Salamanca, Spain)

12:39

P7

THE SEQUESTOSOME 1 MUTATION P392L IS HETEROZYGOUS IN THE AFFECTED TISSUE
M Seton, M Smilewska, A Merchant, J Delany and M Hansen (Farmington, USA)

12:47

P8

CHANGES IN GENE EXPRESSION IN PAGETIC OSTEOBLASTS AND STROMAL CELLS
U Bava, D Naot, K E Callon, G D Gamble, D Wattie, I R Reid, R P Pitto, S A McCowan, T Cundy, J Cornish (Auckland, New Zealand)

12:55-14:30

Lunch and posters

14:30-15:10

Experimental models

Chairs: Richard Keen (London, UK)/Fred Singer (Los Angeles, USA)

14:30

IS6

EXPERIMENTAL MODELS OF PAGET’S DISEASE
David Roodman (Pittsburgh, USA)

15:00

P9

CANINE DISTEMPER VIRUS DOSE-DEPENDENTLY INCREASES HUMAN OSTEOCLAST FORMATION AND FUNCTION IN VITRO
A P Mee (Manchester, UK)

15:10-16:00

Clinical features and diagnosis

Chairs: Roger Francis (Newcastle upon Tyne, UK)/Roger Smith (Oxford, UK)

15:10

IS7

MRI OF PAGET’S DISEASE OF BONE
Sarah Burnett (London, UK)

15:40

P10

WHAT DOES THE BONE SCAN TELL US WHEN MONITORING PAGET’S DISEASE
D Pearson D Hosking K Griffiths (Nottingham, UK)

15:50

P11

PAGET DISEASE OF BONE: CLINICAL FEATURES IN A HIGH PREVALENCE FOCUS
J del Pino-Montes, L Corral, A Carpio, M J García-Rodríguez, L Pozo, C A Montilla (Salamanca, Spain)

16:00

Tea

16:30-17:00

The PRISM Study

Chairs: Michael Davie (Oswestry, UK)/Eugene McCloskey (Sheffield, UK)

16:30

IS8

THE PRISM STUDY: BASELINE ANALYSIS AND IDENTIFICATION OF CLINICAL PREDICTORS OF QUALITY OF LIFE
Anne Langston (Aberdeen, UK)

17:00

Keynote Lecture

Chairs: Michael Davies (Manchester, UK)/Allan Dixon (Truro, UK)

THE PAGET FAMILY ACROSS THE GENERATIONS
Sir Julian Paget

17:30

Close

19.30

Reception and Conference Dinner

Saturday 9 July 2005

09:00-10:30

Advances in biology and pharmacology related to Paget’s disease

Chairs: Claus Christiansen (Ballerup, Denmark)/Graham Russell (Oxford, UK)

09:00

IS9

BONE STRUCTURE AND REMODELING IN PAGET'S DISEASE - QUALITATIVE AND QUANTITATIVE ABNORMALITIES IN OSTEOBLAST FUNCTION
Michael Parfitt (Little Rock, USA)

09:30

IS10

BISPHOSPHONATE PHARMACOLOGY
Jonathan Green (Basel, Switzerland)

10:00

IS11

BISPHOSPHONATE ACTIONS AND PAGET’S DISEASE
Michael Rogers (Aberdeen, UK)

10:30

Coffee

11:00-12:30

Advances in treatment

Chairs: Richard Eastell (Sheffield, UK)/Ian Reid (Auckland, New Zealand)

11:00

P12

THE UTILITY OF MEASURING BONE BIOMARKERS (PROCOLLAGEN TYPE 1 N-TERMINAL PROPEPTIDE AND N-TERMINAL TELOPEPTIDE OF TYPE 1 COLLAGEN) TO ASSESS THE LONG TERM EFFECTS OF BISPHOSPHONATE TREATMENT ON BONE TURNOVER IN PAGET'S DISEASE
J A Riordan, B F Murray, M J Mc Kenna, T J Mc Kenna (Dublin, Ireland)

11:10

P13

TREATMENT COSTS OF PAGET'S DISEASE AS A MEASURE OF MORBIDITY
B Briesacher, D Orwig, M Seton, M Omar, K Kahler (Massachusetts, Maryland, Boston and East Hanover, USA)

11:20

P14

ASSESSMENT OF THE USE OF BISPHOSPHONATES IN THE MANAGEMENT OF PAGET’S DISEASE OF BONE – THE DEVELOPMENT OF CLINICAL STUDY METHODOLOGIES TO ASSESS EFFICACY AND SAFETY
P Richardson, K Zelenakas (Tokyo, Japan and East Hanover, USA)

11:30

IS12

EFFECTS OF ZOLEDRONATE/RISEDRONATE ON QUALITY OF LIFE IN PAGET'S DISEASE OF BONE

Ken Lyles (Durham, USA)

12:00

IS13

ZOLEDRONATE AND RISEDRONATE IN THE TREATMENT OF PAGET'S DISEASE
David Hosking (Nottingham, UK)

12:30

Close and lunch

ADDITIONAL POSTERS

P15

MORBIDITY IN PATIENTS WITH PAGET'S DISEASE PRESENTING WITH AND WITHOUT SYMPTOMS
M Seton, D Dorer, C Cooper (Massachusetts, USA and Southampton, UK)

P16

CARDIOVASCULAR COMPLICATIONS OF PAGET'S DISEASE OF BONE
D Merlotti, L Gennari, R Valenti, A Palazzuoli, B Galli, C Pondrelli, E Ceccarelli, A Calabrò, V De Paola, G Martini, R Nuti (Siena, Italy)

P17

CLINICAL CRITERIA FOR THE DIAGNOSIS OF PAGETIC BONE PAIN: SURVEY OF COLLABORATING CENTRES IN THE PRISM STUDY
A L Langston, M K Campbell, W D Fraser, P L Selby, S H Ralston, and The PRISM Trial Group (Aberdeen, Liverpool, Manchester and Edinburgh, UK)

P18

SECULAR CHANGES IN PAGET S DISEASE OF BONE IN OUR AREA
A Conesa, D Rotés Sala, J M Manresa, M P Lisbona, L Pérez Edo, J Carbonell (Barcelona, Spain)

P19

PREVALENCE OF PAGET'S DISEASE OF BONE IN ITALY
M Di Stefano, L Gennari, D Merlotti, G Martini, C Tamone, S Bergui, R Zatteri, R De Lucchi, C Baldi,A Vattimo, L Burroni, V De Paola, S Calabrò, A Avanzati, R Nuti, G C Isaia (Turin and Siena, Italy)

P20

PAGET'S DISEASE IN AN ASIAN IN THE UK
S J Iqbal, S Mulhbayer G McHugh, R Oldham and D Finlay (Leicester, UK)