Thursday 17 July

09:00-11:18

Epidemiology
Chairs: Steven Cummings/David Hosking

09:00

IS1

EPIDEMIOLOGY: US PERSPECTIVE

Bob Tiegs (Rochester MN, USA)

09:30

IS2

EPIDEMIOLOGY: REVIEW

Tim Cundy (Auckland, New Zealand)

10:00

IS3

EPIDEMIOLOGY OF CLINICAL COMPLICATIONS

Cyrus Cooper (Southampton, UK)

10:30

Oral communications
Chairs: Steven Cummings/David Hosking

10:30

1

PAGET'S CASES IN THE SE LONDON COMMUNITY IDENTIFIED BY ISOLATED RAISED TOTAL SERUM ALKALINE PHOSPHATASE

C Moniz, R Chandra, T Mangion, B Bowden. Clinical Biochemistry, Kings College Hospital, London, UK

10:38

2

CLINICAL ASPECTS AND COMPLICATIONS OF PAGET'S DISEASE:A REVIEW OF 100 PATIENTS IN HUNGARY

J Donáth, P Gergely Jr, G Poór. National Institute of Rheumatology and Physiotherapy, Budapest, Hungary

10:46

3

PREVALENCE AND CLINICAL FEATURES OF PAGET'S DISEASE OF BONE IN JAPAN

J Hashimoto, I Ohno, K Nakatsuka, N Yoshimura, K Yoh, M Fukunaga, S Takata, M Terada, H Yabe, S Abe, M Zamma, H Yoshikawa. The Committee on clinical guideline of diagnosis and treatment of Paget's disease of bone in Japan

10:54

4

CHARACTERISTICS AND FAMILIAL AGGREGATION OF PAGET'S DISEASE OF BONE IN ITALY

D Merlotti, B Galli, F Cipolli, F Iovine, N Dal Canto, A Spinola, L Gennari, R Valenti, G Martini, R  Nuti. Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Italy

11:02

5

RADIOLOGICAL PREVALENCE OF PELVIC PAGET'S DISEASE IN ITALY

L Gennari^[1], S Geraci^[1],  D Merlotti^[1],  N Giordano^[1],  C Baldi^[2],  S Capoccia^[2],  A Amendola^[1],  G Martini^[1],  R Nuti^[1]. ^[1]Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry; ^[2]Department of Radiology, University of Siena, Italy

11:10

6

CHANGES IN FREQUENCY OF MONOSTOTIC DISEASE AND AGE AT PRESENTATION OF PAGET'S DISEASE OF BONE OVER 20YEARS

M W J Davie^[1], M J Haddaway^[2], I W McCall^[2]. ^[1]Charles Salt Centre for Bone Metabolism; ^[2]Department of Diagnostic Imaging, Robert Jones & Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire, UK.

11:18

Coffee and posters

11:45-12:45

Slow virus infections and Paget’s disease
Chairs: Nick Athanasou/Ian Reid

11:45

IS4

PARAMYXOVIRUSES AND PAGET’S DISEASE

Bert Rima (Belfast, UK)

12:15

IS5

HOW MIGHT VIRUSES CAUSE PAGET’S DISEASE?

David Roodman (Pittsburgh PA, USA)

12:45

Lunch and posters

14:00-15:26

Genetics
Chairs: Jacques Brown/Stuart Ralston

14:00

IS6

OVERVIEW OF PAGET’S GENETICS

Wim Van Hul (Antwerp, Belgium)

14:30

Oral communications

14:30

7

FINE MAPPING OF PDB5 & PDB6 LOCI IN FAMILIAL PAGET'S DISEASE OF BONE

L J Hocking, S H Ralston. Department of Medicine and Therapeutics, University of Aberdeen, UK

14:38

8

GENETIC HETEROGENEITY OF PAGET DISEASE OF BONE IN FRENCH-CANADIAN FAMILIES

J Morissette, N Laurin, S Auger, V Raymond, J P Brown. Centre de recherche du CHUL, Université Laval, Québec, P.Q., Canada

14:46

9

LARGE PHENOTYPIC VARIABILITY OF PAGET DISEASE OF BONE CAUSED BY THE P392L SEQUESTOSOME1/P62 MUTATION

N Laurin, J Morissette, V Raymond, J P Brown. Centre de recherche du CHUL, Université Laval, Québec, P.Q., Canada

14:54

10

STRUCTURE/FUNCTION ANALYSIS OF THE UBIQUITIN-ASSOCIATED DOMAIN OF THE P62/SQSTM1 PROTEIN

J R Cavey^[1], B Ciani^[2], M S Searle^[2], P W Sheppard^[3], S H Ralston^[4], R Layfield^[1]. ^[1]School of Biomedical Sciences; ^[2]Department of Chemistry, University of Nottingham, UK; ^[3]Affiniti Research Products Ltd, Palatine House, Matford Court, Exeter, UK; ^[4]Department of Medicine and Therapeutics, University of Aberdeen, UK

15:02

11

EVIDENCE OF AN ALLELIC ASSOCIATION BETWEEN SINGLE NUCLEOTIDE POLYMORPHISMS IN EXON6 OF SQSTM1/P62 AND PAGET'S DISEASE OF BONE.

G J A Lucas, L J Hocking, A Daroszewska, S H Ralston. University of Aberdeen, UK.

15:10

12

MUTATIONS IN THE SEQUESTOSOME 1 GENE ARE NOT COMMON IN ISOLATED BELGIAN PATIENTS WITH PAGET'S DISEASE.

G Beyens^[1], E Van Hul^[1], E Cleiren^[1], J P Devogelaer^[2], F Vanhoenacker^[3], L De Clerck^[3], J Van Offel^[3], L Verbruggen^[4], W Van Hul^[1]. ^[1]Department of Medical Genetics, University of Antwerp, Belgium; ^[2]University Hospitals Saint-Luc, Brussels, Belgium; [3 University hospital of Antwerp, Belgium; ^[4]University Hospital of Brussels, Belgium

15:18

13

RECURRENT SQSTM1 GENE MUTATION AT CODON 392 IN PAGET'S DISEASE OF BONE

L Gennari, V De Paola, A Calabrò, D Merlotti, G Martini, R Valenti, S Salvadori, R Nuti. Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Italy

15:26

Tea

Chairs: Stephen Krane/Jack Martin

16:00

IS7

FAMILIAL EXPANSILE OSTEOLYSIS AND RANK

Anne Hughes (Belfast, UK)

16:30

IS8

JUVENILE PAGET’S – GENOTYPE/PHENOTYPE RELATIONSHIPS

Michael Whyte (St Louis MO, USA)

17:00

Oral communications
Chairs: Stephen Krane/Jack Martin

17:00

14

PHENOTYPIC CHARACTERISATION OF EARLY ONSET PAGETS DISEASE OF BONE CAUSED BY A 27BP DUPLICATION IN THE TNFRSF11A GENE

K Nakatsuka^[1], Y Nishizawa^[1], S H Ralston^[2], ^[1]Osaka City University, Osaka, Japan; ^[2]University of Aberdeen, UK

17:08

15

SUSCEPTIBILITY TO PAGET'S DISEASE OF BONE IS INFLUENCED BY OSTEOPROTEGERIN POLYMORPHISM

A Daroszewska^[1], L J Hocking^[1], F E A McGuigan^[1], B Langdahl^[2], M D Stone^[3], W D Fraser^[4], S H Ralston^[1]. ^[1]Department of Medicine and Therapeutics, University of Aberdeen, UK; ^[2]Department of Endocrinology, Aarhus Amtssygehus, Denmark; ^[3]University of Wales College of Medicine, Cardiff, UK; ^[4]Department of Clinical Chemistry, University of Liverpool, UK

17:16

16

PAGETIC BONE STROMAL CELLS EXPRESS RANKL AND SUPPORT OSTEOCLAST FORMATION FROM CIRCULATING PRECURSORS

I Itonaga, A Sabokbar, SG Sun, NA Athanasou. Department of Pathology, Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, University of Oxford, Oxford OX3 7LD, UK

17:24

17

GENE EXPRESSION IN THE PAGETIC OSTEOBLAST

U Bava^[1], D Naot^[1], K E Callon^[1], R P Pitto^[2], S A McCowan^[3], T Cundy^[1], I R Reid^[1], J Cornish^[1]. ^[1]Department of Medicine; ^[2]Department of Surgery; ^[3]Department of Orthopaedics, Auckland Hospital, New Zealand

17:45

Keynote lecture
Chairs: Graham Russell/Roger Smith

PAGET’S DISEASE: WHAT HAVE WE LEARNT OVER THE LAST 30 YEARS?

Stephen Krane (Boston MA, USA)

18:30

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